Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.

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TitreAdenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.
Publication TypeJournal Article
Année de Publication2010
AuthorsGoldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen J-F, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M
JournalNat Neurosci
Volume13
Issue7
Pagination883-8
Date Published2010 Jul
ISSN1546-1726
Mots-clésAcupuncture Analgesia, Adenosine, Afferent Pathways, Analysis of Variance, Animals, Disease Models, Animal, Mice, Nucleotidases, Pain, Pain Management, Peripheral Nervous System Diseases, Receptors, Purinergic P1, Sciatica, Statistics, Nonparametric
Résumé

Acupuncture is an invasive procedure commonly used to relieve pain. Acupuncture is practiced worldwide, despite difficulties in reconciling its principles with evidence-based medicine. We found that adenosine, a neuromodulator with anti-nociceptive properties, was released during acupuncture in mice and that its anti-nociceptive actions required adenosine A1 receptor expression. Direct injection of an adenosine A1 receptor agonist replicated the analgesic effect of acupuncture. Inhibition of enzymes involved in adenosine degradation potentiated the acupuncture-elicited increase in adenosine, as well as its anti-nociceptive effect. These observations indicate that adenosine mediates the effects of acupuncture and that interfering with adenosine metabolism may prolong the clinical benefit of acupuncture.

DOI10.1038/nn.2562
PubMed ID20512135
PubMed Central IDPMC3467968
Grant ListR01 ES014899 / ES / NIEHS NIH HHS / United States
R01 ES014899-04 / ES / NIEHS NIH HHS / United States
R01 NS075177 / NS / NINDS NIH HHS / United States
R21 ES017470 / ES / NIEHS NIH HHS / United States
R21 ES017470-01 / ES / NIEHS NIH HHS / United States
Z99 DK999999 / / Intramural NIH HHS / United States